Uncoupling proteins (UCPs) regulate mitochondrial function, and thus cellular metabolism. Angiotensin‐converting enzyme (ACE) is the central component of endocrine and local tissue renin–angiotensin systems (RAS), which also regulate diverse aspects of whole‐body metabolism and mitochondrial function (partly through altering mitochondrial UCP expression). We show that ACE expression also appears to be regulated by mitochondrial UCPs. In genetic analysis of two unrelated populations (healthy young UK men and Scandinavian diabetic patients) serum ACE (sACE) activity was significantly higher amongst UCP3‐55C (rather than (...) T) and UCP2 I (rather than D) allele carriers. RNA interference against UCP2 in human umbilical vein endothelial cells reduced UCP2 mRNA sixfold (P < 0·01) whilst increasing ACE expression within a physiological range (<1·8‐fold at 48 h; P < 0·01). Our findings suggest novel hypotheses. Firstly, cellular feedback regulation may occur between UCPs and ACE. Secondly, cellular UCP regulation of sACE suggests a novel means of crosstalk between (and mutual regulation of) cellular and endocrine metabolism. This might partly explain the reduced risk of developing diabetes and metabolic syndrome with RAS antagonists and offer insight into the origins of cardiovascular disease in which UCPs and ACE both play a role. (shrink)

Secreted Frizzled‐related proteins (SFRPs) are modulators of the intermeshing pathways in which signals are transduced by Wnt ligands through Frizzled (Fz) membrane receptors. The Wnt networks influence biological processes ranging from developmental cell fate, cell polarity and adhesion to tumorigenesis and apoptosis. In the five or six years since their discovery, the SFRPs have emerged as dynamically expressed proteins able to bind both Wnts and Fz, with distinctive structural properties in which cysteine‐rich domains from Fz‐ and from netrin‐like proteins are (...) juxtaposed. The abundant expression of SFRP genes in the early embryo, altered expression patterns in disease states, and potential significance in the evolution of the vertebrate body plan, make these intriguing molecules relevant to investigations in diverse fields of biology and biomedical sciences. BioEssays 24:811–820, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

Recombinant DNA technology can now be applied to the analysis of complex human diseases such as polygenic disorders, where the inheritance of several unknown genes appears to be involved. We review here the progress in the analysis of genes which may be involved in the development of hyperlipidaemia, and show how the approach may be important in our understanding of the aetiology of coronary artery disease.

Moral judgments about an agent's behavior are enmeshed with inferences about the agent's mind. Folk psychology—the system that enables such inferences—therefore lies at the heart of moral judgment. We examine three related folk-psychological concepts that together shape people's judgments of blame: intentionality, choice, and free will. We discuss people's understanding and use of these concepts, address recent findings that challenge the autonomous role of these concepts in moral judgment, and conclude that choice is the fundamental concept of the three, defining (...) the core of folk psychology in moral judgment. (shrink)

Based on an original ethnographic study of a translational cancer research institute in the United States, we propose calibration as a process that makes interdisciplinary collaboration without consensus possible. Calibration refers to ongoing, day-to-day negotiation and alignment of personal identities, disciplinary commitments, and research group customs that occur during face-to-face group deliberations around everyday research concerns. Calibration provides a mechanism that explains how collaboration without consensus is possible. Crucially, it does not presuppose that interdisciplinary collaboration either indicates or causes the (...) blurring or softening of disciplinary boundaries. We argue that at the microsociological level it may be disciplinary robustness, rather than synthesis, that contributes to interdisciplinary innovation. (shrink)

While there is now general agreement that memory gives rise to both conscious and unconscious influences, there remains disagreement concerning the process architecture underlying these distinct influences. Do they arise from independent underlying systems or from systems that are interactive ? In the current paper we present a novel “inside-out” technique that can be used with the process-dissociation paradigm to arrive at more concrete conclusions concerning this central question and demonstrate this technique via a meta-analysis of currently published findings. Our (...) results suggest that the data presented in these studies vary in ways most consistent with the assumption that conscious and unconscious influences behave independently. (shrink)

System-level change is crucial for solving society's most pressing problems. However, individual-level interventions may be useful for creating behavioral change before system-level change is in place and for increasing necessary public support for system-level solutions. Participating in individual-level solutions may increase support for system-level solutions – especially if the individual-level solutions are internalized as part of one's social identity.

In this article, the authors utilize the philosophical methodology developed by Michael Hardt and Antonio Negri to formulate a theory of educational realism. The goal is to posit an embodied form of education that emerges from within the movements of the multitude. The connection between multitudinous movement and education is the concept of choreography, which destabilizes habituated movements, unleashing creative alternatives. The paper concludes with several examples of choreography as an exopedagogy for cultivating embodied, swarm intelligence from the work of (...) noted choreographer William Forsythe. (shrink)

Why do marketing managers in the transitional economies of Eastern Europe and China often engage in competitively irrational behavior, choosing pricing strategies that damage competitors’ profits, rather than choosing pricing strategies that improve their firm’s profits? We propose one possible reason, the moral vacuum created by the collapse of communist ideology. We hypothesize and find that managers who experienced formal communist moral ideological indoctrination are less likely to be competitively irrational than the post-communist managers who did not. Implications are discussed.

Evidence‐based interventions have been developed and used to prevent HIV infections among black men who have sex with men (MSM) in Canada and the United States; however, the degree to which interventions address racism and other interlocking oppressions that influence HIV vulnerability is not well known. We utilize integrative antiracism to guide a review of HIV prevention intervention studies with black MSM and to determine how racism and religious oppression are addressed in the current intervention evidence base. We searched CINAHL, (...) PsychInfo, MEDLINE and the CDC compendium of evidence‐based HIV prevention interventions and identified seventeen interventions. Three interventions targeted black MSM, yet only one intervention addressed racism, religious oppression, cultural assets and religious assets. Most interventions' samples included low numbers of black MSM. More research is needed on interventions that address racism and religious oppression on HIV vulnerability among black MSM. Future research should focus on explicating mechanisms by which multiple oppressions impact HIV vulnerability. We recommend the development and integration of social justice tools for nursing practice that aid in addressing the impacts of racism and other oppressions on HIV vulnerability of black MSM. (shrink)

Extant models of moral judgment assume that an action’s intentionality precedes assignments of blame. Knobe (2003b) challenged this fundamental order and proposed instead that the badness or blameworthiness of an action directs (and thus unduly biases) people’s intentionality judgments. His and other researchers’ studies suggested that blameworthy actions are considered intentional even when the agent lacks skill (e.g., killing somebody with a lucky shot) whereas equivalent neutral actions are not (e.g., luckily hitting a bull’s-eye). The present five studies offer an (...) alternative account of these provocative findings. We suggest that people see the morally significant action examined in previous studies (killing) as accomplished by a basic action (pressing the trigger) for which an unskilled agent still has sufficient skill. Studies 1 through 3 show that when this basic action is performed unskillfully or is absent, people are far less likely to view the killing as intentional, demonstrating that intentionality judgments, even about immoral actions, are guided by skill information. Studies 4 and 5 further show that a neutral action such as hitting the bull’s-eye is more difficult than killing and that difficult actions are less often judged intentional. When difficulty is held constant, people’s intentionality judgments are fully responsive to skill information regardless of moral valence. The present studies thus speak against the hypothesis of a moral evaluation bias in intentionality judgments and instead document people’s sensitivity to subtle features of human action. (shrink)

Are people with flawed faces regarded as having flawed moral characters? An “anomalous-is-bad” stereotype is hypothesized to facilitate negative biases against people with facial anomalies (e.g., scars), but whether and how these biases affect behavior and brain functioning remain open questions. We examined responses to anomalous faces in the brain (using a visual oddball paradigm), behavior (in economic games), and attitudes. At the level of the brain, the amygdala demonstrated a specific neural response to anomalous faces—sensitive to disgust and a (...) lack of beauty but independent of responses to salience or arousal. At the level of behavior, people with anomalous faces were subjected to less prosociality from participants highest in socioeconomic status. At the level of attitudes, we replicated previously reported negative character evaluations made about individuals with facial anomalies, and further identified explicit biases directed against them as a group. Across these levels of organization, the specific amygdala response to facial anomalies correlated with stronger just-world beliefs (i.e., people get what they deserve), less dispositional empathic concern, and less prosociality toward people with facial anomalies. Characterizing the “anomalous-is-bad” stereotype at multiple levels of organization can reveal underappreciated psychological burdens shouldered by people who look different. (shrink)

This paper examines from a cognitive perspective the rhetorical and epistemic advantages that can be gained from the use of (extended) metaphors in political discourse. We defend the assumption that extended metaphors can be argumentatively exploited, and provide two arguments in support of the claim. First, considering that each instantiation of the metaphorical mapping in the text may function as a confirmation of the overall relevance of the main core mapping, we argue that extended metaphors carry self-validating claims that increase (...) the chances of their content being accepted. Second, we show how the recognition of an extended metaphor’s sophistication and relevance (on behalf of the addressee) can benefit the speaker’s perceived competence (ethos). We then assess whether these two arguments measure against the dual epistemic monitoring postulated in the notion of epistemic vigilance (i.e., assessment of the source of a message and assessment of the message) and conclude that extended metaphors may fulfil the requirements of epistemic vigilance and lead to the stabilisation of a belief. We illustrate our account with an analysis of the extended metaphor of the USA as an empire found in a political pamphlet written by the Swiss politician Oskar Freysinger. (shrink)

A Brief History of Analytic Philosophy: From Russell to Rawls presents a comprehensive overview of the historical development of all major aspects of analytic philosophy, the dominant Anglo-American philosophical tradition in the twentieth century. Features coverage of all the major subject areas and figures in analytic philosophy - including Wittgenstein, Bertrand Russell, G.E. Moore, Gottlob Frege, Carnap, Quine, Davidson, Kripke, Putnam, and many others Contains explanatory background material to help make clear technical philosophical concepts Includes listings of suggested further readings (...) Written in a clear, direct style that presupposes little previous knowledge of philosophy. (shrink)

ABSTRACT The influence of Cassirer's work on Bakhtin's writings from the 1930s has been studied in some detail but scholars have not examined Bakhtin's early work, Toward a Philosophy of the Act (K filosofii postupka), in connection with Cassirer's philosophy. The article first reveals how attuned Bakhtin was with the intellectual Zeitgeist not only of his own times, but also that of the 20th century. The uncanny intellectual harmony between the ideas of Bakhtin and Cassirer can be seen at the (...) very beginning of Bakhtin's career. The two thinkers are united in their reception, transformation, and attempt to reconcile two antithetical philosophical positions dominant at the beginning of the 20th century: the transcendental philosophy of Kant, Neo-Kantianism, and the Lebensphilosophie of Simmel, Bergson, and Heidegger. Bakhtin and Cassirer were alarmed by the cultural pessimism and potential nihilism inherent in the position of Lebensphilosophie. Next, the author shows ways in which Bakhtin's and Cassirer's ideas resonate with those of the later 20th century Jacques Derrida. (shrink)

Quillen [17] introduced model categories as an abstract framework for homotopy theory which would apply to a wide range of mathematical settings. By all accounts this program has been a success and—as, e.g., the work of Voevodsky on the homotopy theory of schemes [15] or the work of Joyal [11, 12] and Lurie [13] on quasicategories seem to indicate—it will likely continue to facilitate mathematical advances. In this paper we present a novel connection between model categories and mathematical logic, inspired (...) by the groupoid model of (intensional) Martin–Löf type theory [14] due to Hofmann and Streicher [9]. In particular, we show that a form of Martin–Löf type theory can be soundly modelled in any model category. This result indicates moreover that any model category has an associated “internal language” which is itself a form of Martin-Löf type theory. This suggests applications both to type theory and to homotopy theory. Because Martin–Löf type theory is, in one form or another, the theoretical basis for many of the computer proof assistants currently in use, such as Coq and Agda (cf. [3] and [5]), this promise of applications is of a practical, as well as theoretical, nature. This paper provides a precise indication of this connection between homotopy theory and logic; a more detailed discussion of these and further results will be given in [20]. (shrink)

Deep brain stimulation of the subthalamic nucleus is a clinically effective tool for treating medically refractory Parkinson’s disease, but its neural mechanisms remain debated. Previous work has demonstrated that STN DBS results in evoked potentials in the primary motor cortex, suggesting that modulation of cortical physiology may be involved in its therapeutic effects. Due to technical challenges presented by high-amplitude DBS artifacts, these EPs are often measured in response to low-frequency stimulation, which is generally ineffective at PD symptom management. This (...) study aims to characterize STN-to-cortex EPs seen during clinically relevant high-frequency STN DBS for PD. Intraoperatively, we applied STN DBS to 6 PD patients while recording electrocorticography from an electrode strip over the ipsilateral central sulcus. Using recently published techniques, we removed large stimulation artifacts to enable quantification of STN-to-cortex EPs. Two cortical EPs were observed – one synchronized with DBS onset and persisting during ongoing stimulation, and one immediately following DBS offset, here termed the “start” and the “end” EPs respectively. The start EP is, to our knowledge, the first long-latency cortical EP reported during ongoing high-frequency DBS. The start and end EPs differ in magnitude and latency, and the end, but not the start, EP magnitude has a significant relationship to ongoing high gamma power during the EP. These contrasts may suggest mechanistic or circuit differences in EP production during the two time periods. This represents a potential framework for relating DBS clinical efficacy to the effects of a variety of stimulation parameters on EPs. (shrink)

An international team of ethicists refresh the debate about human enhancement by examining whether resistance to the use of technology to enhance our mental and physical capabilities can be supported by articulated philosophical reasoning, or explained away, e.g. in terms of psychological influences on moral reasoning.

Following Schelling (1960), coordination problems have mainly been considered in a context where agents can achieve a common goal (e.g., rendezvous) only by taking common actions. Dynamic versions of this problem have been studied by Crawford and Haller (1990), Ponssard (1994), and Kramarz (1996). This paper considers an alternative dynamic formulation in which the common goal (dispersion) can only be achieved by agents taking distinct actions. The goal of spatial dispersion has been studied in static models of habitat selection, location (...) or congestion games, and network analysis. Our results show how this goal can be achieved gradually, by indistinguishable non-communicating agents, in a dynamic setting. (shrink)

Despite inroads made by critical realism against the ‘scientific method’ in social science, the latter remains strong in subject-areas like human resource management. One argument for the alleged superiority of the scientific method (i.e. its scientificity) lies in the taken-for-granted belief that it alone can formulate empirically testable predictions. Many of those who employ the scientific method are, however, confused about the way they understand and practice prediction. This paper takes as a case study empirical research on the alleged empirical (...) association between human resource management practices and organisational performance. By unpacking the confusion surrounding the two basic notions of prediction used, it reveals what is wrong with them, why the scientific method cannot actually make accurate predictions and why, therefore, the scientific method fails to meet its own criteria for scientificity. Finally, explanation is considered in order to prevent any confusion between it and prediction and to offer what we call tendential prediction. (shrink)

The present paper shows that the clearest formulation of J. M. E. McTaggart's antipassage argument, that of D. H. Mellor in _Real Time II, is unsound when its premises are interpreted so that it is valid. This argument need mislead us no longer. The crucial item in the interpretation of the premises is the copula 'is', as in 'E is past'. The copula may be either tensed or tenseless. While this ambiguity of the copula has been noted before, its implications (...) for McTaggart's argument had not been adequately exploited. This paper does that job. (shrink)

As artificial intelligence (AI) thrives and propagates through modern life, a key question to ask is how to include humans in future AI? Despite human involvement at every stage of the production process from conception and design through to implementation, modern AI is still often criticized for its “black box” characteristics. Sometimes, we do not know what really goes on inside or how and why certain conclusions are met. Future AI will face many dilemmas and ethical issues unforeseen by their (...) creators beyond those commonly discussed (e.g., trolley problems and variants of it) and to which solutions cannot be hard-coded and are often still up for debate. Given the sensitivity of such social and ethical dilemmas and the implications of these for human society at large, when and if our AI make the “wrong” choice we need to understand how they got there in order to make corrections and prevent recurrences. This is particularly true in situations where human livelihoods are at stake (e.g., health, well-being, finance, law) or when major individual or household decisions are taken. Doing so requires opening up the “black box” of AI; especially as they act, interact, and adapt in a human world and how they interact with other AI in this world. In this article, we argue for the application of cognitive architectures for ethical AI. In particular, for their potential contributions to AI transparency, explainability, and accountability. We need to understand how our AI get to the solutions they do, and we should seek to do this on a deeper level in terms of the machine-equivalents of motivations, attitudes, values, and so on. The path to future AI is long and winding but it could arrive faster than we think. In order to harness the positive potential outcomes of AI for humans and society (and avoid the negatives), we need to understand AI more fully in the first place and we expect this will simultaneously contribute towards greater understanding of their human counterparts also. (shrink)

We define the notion of a model of higher-order modal logic in an arbitrary elementary topos E. In contrast to the well-known interpretation of higher-order logic, the type of propositions is not interpreted by the subobject classifier ΩE, but rather by a suitable complete Heyting algebra H. The canonical map relating H and ΩE both serves to interpret equality and provides a modal operator on H in the form of a comonad. Examples of such structures arise from surjective geometric morphisms (...) f : F → E, where H = f∗ΩF. The logic differs from non-modal higher-order logic in that the principles of functional and propositional extensionality are not longer valid but may be replaced by modalized versions. The usual Kripke, neighborhood, and sheaf semantics for propositional and first-order modal logic are subsumed by this notion. (shrink)

Tom Six’s The Human Centipede (First Sequence) (2009) and The Human Centipede II (Full Sequence) (2011) are based on a disturbing premise: people are abducted and stitched together mouth-to-anus. The consequent combinations of faeces and bloodshed, torture and degradation have been roundly vilified by the critical press. Additionally, the sequel was officially banned or heavily censored in numerous countries. This article argues that these reactive forms of suppression fail to engage with the films themselves, or the concepts (such as disgust (...) and offense) on which those judgements are made. Six’s films are far more sophisticated than has been accounted for. These films wear their generic lineage on their grimy sleeves, contextualising conventional motifs such as the mad scientist archetype against contemporary cultural anxieties regarding the body, sex and violence. Furthermore, Six’s constructed persona exposes the interplay between commercial success, grotesquery and censoriousness as a cyclic system that can be abused. Thus, the series epitomises how repulsion can be strategically utilised. Six anticipates his detractors’ offense, and disarms them of their ability to critique his films without adding to their notoriety. The Human Centipede films demonstrate how controversy can be tactically generated to create meaning. (shrink)

This paper investigates the tentative compatibility of two pragmatic approaches, Pragma-Dialectics and Relevance Theory. The development of pragmatics historically led to conceptions of communication that supplied answers formal logic approaches had trouble capturing. Within argumentation studies, PD took this pragmatic turn while at the same time pursuing a normative agenda. This gives evidence of an external approach to language excluding, though not closing the door to cognitive insights. The purpose of this paper is to discuss the extent to which PD (...) can operate from an internal cognitive perspective — i.e., with explicit ambitions of dealing with cognitive mechanisms of meaning construction and belief fixation. (shrink)

This article explores the relationship between skin, ego and second skins. It does so conceptually by re-examining Freud’s suggestion, in The Ego and the Id, that the ego is first and foremost a bodily entity, while also being a projection of a surface (i.e. skin). Drawing upon Anzieu, a dynamic model of inter-weaving surfaces can be seen to underpin an understanding of the ego — and skin ego. This model is fundamentally spatialized. Even so, an appreciation of the spatialities of (...) skin and ego can be developed further. To illuminate these spatialities, this article examines two key experiences of T.E. Lawrence during his military service in Arabia (c. 1917), as he describes them in his autobiographical account Seven Pillars of Wisdom. In a meeting with British military police, and in the notorious Deraa rape incident, what is at stake is Lawrence of Arabia’s skins. Reading these experiences using Freud and Anzieu, the article argues that these events re-present an ongoing chafing of Lawrence’s skin, ego and second skins, which can be called his ‘skin of suffering’. (shrink)

During the period of growth of e‐commerce, e‐business and online life in general, trust has been identified by a number of authors as a key factor, the absence of which can act as a powerful disincentive to an individual’s engagement in a transaction. This has encouraged a great deal of research into the various facets of trust in an online environment, both theoretical and empirical. One of the many recommendations for business practice that have emerged from this research is the (...) suggestion that online businesses should publish on their website a privacy policy that explains clearly the use that will be made of any personal information collected on the site, the third parties to whom it may be disclosed, and the circumstances under which disclosure may occur. A number of surveys have been conducted that highlight the rather patchy adoption of this recommendation in various countries. We now know, for example, that by no means all online organisations publish an online privacy policy, and that many of those that do exist display a range of serious shortcomings, including poor visibility on the site, incomplete coverage of the main issues of concern and poor readability. However, previous discussion of privacy policies has tended to assume that any particular policy can provide value to its readers by informing them of the privacy practices of its host organisation, and thus also to its publishers through encouraging customers and clients to trust them more than they otherwise would. This assumption is expected to be valid where the policy meets certain criteria, which are either established on the basis of theoretical considerations, or are derived from a kind of best‐in‐breed comparative exercise. This paper seeks to address the question how far privacy policies can ever achieve the goal of providing clear information to website visitors about the privacy practices of an organisation. It reports on an empirical study that was conducted between November 2005 and April 2006 using two groups of University students as subjects. The subjects were asked to read three privacy policies, selected in advance by the author, and to complete a short questionnaire on what the subject thought each policy had to say about certain key privacy issues. The results reveal that there is surprisingly little agreement about what a policy actually means. This has significant implications both for policy writers and their managers, and also for those who are considering entering into a transaction with the host website. There is a need for further research to investigate this question in more detail, but it is clear from these findings that we know less than we thought we did about the ways in which people interpret the notices that they read on websites. (shrink)

This article briefly examines six centres of learning and witness representing Buddhist, Hindu, Christian, Zoroastrian and Muslim faiths. It explores the implications of five potential insights arising from these historical models for the Asian contexts of today. These insights are approached from the perspective of the Christian world view, but are equally applicable to other faiths. An attempt has been made to do two main things. First is to highlight historically the importance of pre-modern centres of learning and witness that (...) can perhaps also be called universities, or 'proto-universities'. There has also been the desire to encourage the 'Global South' in their history of education, and suggest implications for the future. (shrink)

I focus on the religio-aesthetic concept of nature in Japanese Buddhism as a valuable complement to environmental philosophy in the West and develop an explicit comparison of the Japanese Buddhist concept of nature and the ecological world view of Aldo Leopold. I discuss the profound current of ecological thought running through the Kegon, Tendai, Shingon, Zen, Pure Land, and Nichiren Buddhist traditions as weIl as modem Japanese philosophy as represented by Nishida Kitarö and Watsuji Tetsurö. In this context, I present (...) the Japanese concept of nature as an aesthetic continuum of interdependent events based on a field paradigm of reality. I show how the Japanese concept of nature entails an extension of ethics to include the relation between humans and the land. I argue that in both the Japanese Buddhist concept of nature and the thought of Aldo Leopold there is a hierarchy of normative values which grounds the land ethic in aland aesthetic. I also clarify the soteric concept of nature in Japanese Buddhism by which the natural environment becomes the ultimate locus of salvation for all sentient beings. In this way, I argue that the Japanese Buddhist concept of nature represents a fundamental shift from the egocentric to an ecocentric position-i.e., a de-anthropocentric standpoint which is nature-centered as opposed to human-centered. (shrink)

Three different styles of foundations of mathematics are now commonplace: set theory, type theory, and category theory. How do they relate, and how do they differ? What advantages and disadvantages does each one have over the others? We pursue these questions by considering interpretations of each system into the others and examining the preservation and loss of mathematical content thereby. In order to stay focused on the “big picture”, we merely sketch the overall form of each construction, referring to the (...) literature for details. Each of the three steps considered below is based on more recent logical research than the preceding one. The first step from sets to types is essentially the familiar idea of set theoretic semantics for a syntactic system, i.e. giving a model; we take a brief glance at this step from the current point of view, mainly just to fix ideas and notation. The second step from types to categories is known to categorical logicians as the construction of a “syntactic category”; we give some specifics for the benefit of the reader who is not familiar with it. The third step from categories to sets is based on quite recent work, but captures in a precise way an intuition from the early days of foundational studies. With these pieces in place, we can then draw some conclusions regarding the differences between the three schemes, and their relative merits. In particular, it is possible to state more precisely why the methods of category theory are more appropriate to philosophical structuralism. (shrink)

The interaction between syntax and its semantics is one which has been well studied in categorical logic. The results of this particular study are employed to understand how the brain is able to create meanings. To emphasize the toy character of the proposed model, we prefer to speak of the homunculus brain rather than the brain per se. The homunculus brain consists of neurons, each of which is modeled by a category, and axons between neurons, which are modeled by functors (...) between the corresponding neuron-categories. Each neuron has its own program enabling its working, i.e. a theory of this neuron. In analogy to what is known from categorical logic, we postulate the existence of a pair of adjoint functors, called Lang and Syn, from a category, now called BRAIN, of categories, to a category, now called MIND, of theories. Our homunculus is a kind of “mathematical robot”, the neuronal architecture of which is not important. Its only aim is to provide us with the opportunity to study how such a simple brain-like structure could “create meanings” and perform abstraction operations out of its purely syntactic program. The pair of adjoint functors Lang and Syn model the mutual dependencies between the syntactical structure of a given theory of MIND and the internal logic of its semantics given by a category of BRAIN. In this way, a formal language and its meanings are interwoven with each other in a manner corresponding to the adjointness of the functors Lang and Syn. Higher cognitive functions of abstraction and realization of concepts are also modelled by a corresponding pair of adjoint functors. The categories BRAIN and MIND interact with each other with their entire structures and, at the same time, these very structures are shaped by this interaction. (shrink)

History of the American Physiological Society: The First Century, 1887 - 1987. John R. Brobeck , Orr E. Reynolds , Toby A. Appel; -/- Physiology in the American Context, 1850 - 1940. Gerald L. Geison Walter B. Cannon: The Life and Times of a Young Scientist. Saul Benison , A. Clifford Barger , Elin L. Wolfe; -/- The Development of American Physiology: Scientific Medicine in the Nineteenth Century. W. Bruce Fye; -/- The Investigative Enterprise: Experimental Physiology in Nineteenth-Century Medicine. William (...) Coleman , Frederic L. Holmes. (shrink)

Background: This study tested the core tenets of how facial scars are perceived by characterizing layperson response to faces with scars. The authors predicted that scars closer to highly viewed structures of the face (i.e., upper lip and lower lid), scars aligned against resting facial tension lines, and scars in the middle of anatomical subunits of the face would be rated less favorably. Methods: -/- Volunteers aged 18 years and older from the United States were recruited through Amazon’s Mechanical Turk (...) to complete a face rating survey. Scars were digitally added in different locations and orientations for a total of 14 unique scars added to each face. Each participant rated 50 different faces on confidence, friendliness, and attractiveness. Data were analyzed using linear mixed effects models. Results: -/- A total of 88,850 ratings [82,990 scarred (93.4 percent)] for attractiveness, friendliness, and confidence were analyzed. In univariate linear mixed effects models, the presence of a facial scar did not significantly impact attractiveness (β = 0.016, SE = 0.014, z = 1.089, p = 0.276). A second set of linear mixed effects models identified interactions between location, subunit placement, and orientation to facial tension lines. Scars located on the lower lid mid subunit perpendicular to facial tension lines were rated less attractive (β = −0.065, SE = 0.028, z = −2.293, p = 0.022). Conclusions: -/- On average, a single well-healed facial scar does not negatively affect first impressions of attractiveness, confidence, or friendliness. Specific scar location and orientation combinations, however, such as a perpendicular scar at the mid-lower eyelid, may result in lower perceived attractiveness, confidence, and friendliness. (shrink)

Social grooming is an important element of social life in terrestrial primates, inducing the putative benefits of β-endorphin stimulation and group harmony and cohesion. Implicit in many analyses of grooming (e.g. biological markets) are the assumptions of costs and benefits to grooming behaviour. Here, in a review of literature, we investigate the proximate costs and benefits of grooming, as a potentially useful explanatory substrate to the well-documented ultimate (functional) explanations. We find that the hedonic benefits of grooming are well documented. (...) However, we did not find convincing evidence for costs. If proximate costs do exist, they might consist of energetic, cognitive, opportunity costs, or some combination of all of these. Nonetheless, there remains the possibility that grooming costs are negligible, or even that the provision of allogrooming is rewarding in itself. We suggest empirical research to resolve this issue. (shrink)